Systemic release of high mobility group box 1 protein during severe murine influenza.
Identifieur interne : 001220 ( Main/Exploration ); précédent : 001219; suivant : 001221Systemic release of high mobility group box 1 protein during severe murine influenza.
Auteurs : Lisa M. Alleva [Australie] ; Alison C. Budd ; Ian A. ClarkSource :
- Journal of immunology (Baltimore, Md. : 1950) [ 1550-6606 ] ; 2008.
Descripteurs français
- KwdFr :
- Animaux, Autoanticorps (sang), Grippe humaine (immunologie), Grippe humaine (mortalité), Grippe humaine (métabolisme), Grippe humaine (sang), Grippe humaine (virologie), Humains, Infections à Orthomyxoviridae (immunologie), Infections à Orthomyxoviridae (mortalité), Infections à Orthomyxoviridae (métabolisme), Infections à Orthomyxoviridae (sang), Lipopolysaccharides (toxicité), Modèles animaux de maladie humaine, Mâle, Protéine HMGB1 (immunologie), Protéine HMGB1 (métabolisme), Protéine HMGB1 (sang), Pyruvates (pharmacologie), Souris, Souris de lignée BALB C, Sous-type H2N2 du virus de la grippe A, Test ELISA.
- MESH :
- immunologie : Grippe humaine, Infections à Orthomyxoviridae, Protéine HMGB1.
- mortalité : Grippe humaine, Infections à Orthomyxoviridae.
- métabolisme : Grippe humaine, Infections à Orthomyxoviridae, Protéine HMGB1.
- pharmacologie : Pyruvates.
- sang : Autoanticorps, Grippe humaine, Infections à Orthomyxoviridae, Protéine HMGB1.
- toxicité : Lipopolysaccharides.
- virologie : Grippe humaine.
- Animaux, Humains, Modèles animaux de maladie humaine, Mâle, Souris, Souris de lignée BALB C, Sous-type H2N2 du virus de la grippe A, Test ELISA.
English descriptors
- KwdEn :
- Animals, Autoantibodies (blood), Disease Models, Animal, Enzyme-Linked Immunosorbent Assay, HMGB1 Protein (blood), HMGB1 Protein (immunology), HMGB1 Protein (metabolism), Humans, Influenza A Virus, H2N2 Subtype, Influenza, Human (blood), Influenza, Human (immunology), Influenza, Human (metabolism), Influenza, Human (mortality), Influenza, Human (virology), Lipopolysaccharides (toxicity), Male, Mice, Mice, Inbred BALB C, Orthomyxoviridae Infections (blood), Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (metabolism), Orthomyxoviridae Infections (mortality), Pyruvates (pharmacology).
- MESH :
- chemical , blood : Autoantibodies, HMGB1 Protein.
- chemical , immunology : HMGB1 Protein.
- chemical , metabolism : HMGB1 Protein.
- blood : Influenza, Human, Orthomyxoviridae Infections.
- immunology : Influenza, Human, Orthomyxoviridae Infections.
- metabolism : Influenza, Human, Orthomyxoviridae Infections.
- mortality : Influenza, Human, Orthomyxoviridae Infections.
- chemical , pharmacology : Pyruvates.
- chemical , toxicity : Lipopolysaccharides.
- virology : Influenza, Human.
- Animals, Disease Models, Animal, Enzyme-Linked Immunosorbent Assay, Humans, Influenza A Virus, H2N2 Subtype, Male, Mice, Mice, Inbred BALB C.
Abstract
Hypercytokinemia is gaining recognition as the mechanism of fatality from influenza. No work to date has addressed the role of high mobility group box 1 protein (HMGB1) in influenza, the parallel being that in other severe proinflammatory cytokine syndromes (e.g., sepsis and malaria) levels of circulating HMGB1 are elevated and may correlate with death. Using a commercially available ELISA for HMGB1, we found that HMGB1 was not increased in the plasma of influenza virus-infected mice (A/Japan/305/57) on day 7 post infection, about the time of peak mortality, and peak levels of HMGB1 in the plasma did not occur until relatively late in infection, on day 9 post infection. In keeping with the late peak of HMGB1 being unassociated with mortality, administration of ethyl pyruvate, which inhibits active secretion but not passive release of HMGB1, to influenza virus-infected mice, did not affect their survival. Further work is required to determine whether influenza virus infection induces passive release of HMGB1, and whether HMGB1 neutralization with a specific Ab would improve survival.
DOI: 10.4049/jimmunol.181.2.1454
PubMed: 18606700
Affiliations:
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Le document en format XML
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ELISA</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hypercytokinemia is gaining recognition as the mechanism of fatality from influenza. No work to date has addressed the role of high mobility group box 1 protein (HMGB1) in influenza, the parallel being that in other severe proinflammatory cytokine syndromes (e.g., sepsis and malaria) levels of circulating HMGB1 are elevated and may correlate with death. Using a commercially available ELISA for HMGB1, we found that HMGB1 was not increased in the plasma of influenza virus-infected mice (A/Japan/305/57) on day 7 post infection, about the time of peak mortality, and peak levels of HMGB1 in the plasma did not occur until relatively late in infection, on day 9 post infection. In keeping with the late peak of HMGB1 being unassociated with mortality, administration of ethyl pyruvate, which inhibits active secretion but not passive release of HMGB1, to influenza virus-infected mice, did not affect their survival. Further work is required to determine whether influenza virus infection induces passive release of HMGB1, and whether HMGB1 neutralization with a specific Ab would improve survival.</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><noCountry><name sortKey="Budd, Alison C" sort="Budd, Alison C" uniqKey="Budd A" first="Alison C" last="Budd">Alison C. Budd</name><name sortKey="Clark, Ian A" sort="Clark, Ian A" uniqKey="Clark I" first="Ian A" last="Clark">Ian A. Clark</name></noCountry><country name="Australie"><noRegion><name sortKey="Alleva, Lisa M" sort="Alleva, Lisa M" uniqKey="Alleva L" first="Lisa M" last="Alleva">Lisa M. Alleva</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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